Synergistic Effect of Propolis Extract and Antibiotics on Multi-Resist Klebsiella Pneumoniae Strain Isolated fom Wound

This study has been done to evaluate the in vitro activity of synergistic effect between ethanolic extracts of Propolis and 12 different antibiotic drugs against multi-resistant Klebsiella pneumoniae isolated from infected wounds; this evaluation was done by Agar well-diffusion method and Disc diffusion method. The results of this study showed that the isolation bacteria were resisted to most antibiotics which used in this experiment; especially that drugs containing β-lactam ring. Results of this study showed that alcoholic extracts of Propolis increase the inhibition zones of all antibiotics; and the sensitivity of bacteria increase by direct correlation with the increase in the concentration of alcoholic extract of Propolis. Keywords: Synergistic effect, Propolis, Antibiotics, Multi-resistance, Klebsiella pneumonia

Synergistic Effect of Propolis Extract and Antibiotics on Multi-resist Klebsiella pneumoniae Strain Isolated from Wound

This study has been done to evaluate the in vitro activity of synergistic effect between ethanolic extracts of Propolis and 12 different antibiotic drugs against multi-resistant Klebsiella pneumoniae isolated from infected wounds; this evaluation was done by Agar well-diffusion method and Disc diffusion method.The results of this study showed that the isolation bacteria were resisted to most antibiotics which used in this experiment; especially that drugs containing β-lactam ring. Results of this study showed that alcoholic extracts of Propolis increase the inhibition zones of all antibiotics; and the sensitivity of bacteria increase by direct correlation with the increase in the concentration of alcoholic extract of Propolis. Keywords: Synergistic effect, Propolis, Antibiotics, Multi-resistance, Klebsiella pneumonia

The Importance of Character Education for Tweens as Consumers

Tweens is a term that denotes a market segment mentality that falls between children at the lower end and teens at the upper end. Tweens marketing strategies are considered critical for most global brands. Advocates against excessive consumerism and materialism polluting innocent childhood, specifically tweens, call for values implantation through character education in the school to breed more educated consumers. The effect of implanting character building programs in schools on the consumer behavior of the exposed children in the marketplace, however, has never been tested before. This research endeavor is, in essence, an overlap between consumer behavior and educational psychology, investigating the link between personality and behavior in the market. It falls under both positivist and interpretive consumer research, specifically the consumer socialization of children. The aim of this work is to develop a conceptual model linking character education to purchasing lifestyles and consumption patterns of the exposed children as consumers. Following, prospects for future research are highlighted.Educational psychology, character education, attitudes and lifestyles, opinion-leadership, humanitarianism, ethnocentrism, adolescents and middle schools

Efektifitas Pembelajaran Creative Problem Solving Berbasis Eksprimen dalam Pembelajaran Fisika untuk Melatihkan Literasi Teknologi Siswa

Telah dilakukan penelitian tentang dampak penerapan pembelajaran Creative Problem Solving berbasis eksprimen pada konsep hambatan jenis terhadap kemampuan literasi teknologi siswa. Desain eksprimen yang digunakan adalah one group posttest only design. Subyek penelitian adalah 32 siswa SMP di propinsi Riau. Instrumen penelitian yang digunakan adalah tes literasi teknologi tentang konsep hambatan jenis dalam bentuk tes uraian essay yang diberikan kepada kelompok siswa setelah treatment berupa pembelajaran Creative Problem Solving berbasis Eksprimen. Dari hasil analisis statistik diketahui bahwa persentase kuantitas siswa yang mencapai skor diatas 75 untuk skor ideal 100 berjumlah 68,75 %. Hasil penelitian ini menunjukkan bahwa Creative Problem Solving berbasis eksprimen merupakan salah satu metode pembelajaran yang cukup efektif untuk digunakan dalam rangka melatihkan literasi teknologi siswa dalam pembelajaran fisika

Experimental investigation of the mechanical micro structural and thermal properties of thin CrAIN layers deposited by PVD technique for various aluminum percentages

The thin film of chromium nitride and their derivatives obtained by the filing process physical vapor deposition attract more and more attention from industry given their high resistance to wear. This quality of these coatings may be linked to their good mechanical and tribological properties. Several experimental investigations have led to the development of CrAlN (Chronium Aluminum Nitride) hard coatings by varying the aluminum target bias voltage, in preference to the traditional CrN coating. The present work is based on the investigation of physical and mechanical properties of CrAlN coating deposited on a silicon substrate and the effect of the aluminum proportion on their variation. The results demonstrate that variation in aluminum proportion alters the resulting columnar morphology, porosity and the thermal properties. The correlation between aluminum proportions in CrAlN coatings and his thermal properties revealed that the conductivity and the diffusivity are influenced primarily by size and shape distribution of the pores and secondarily by decrease of the stitch parameter dimension

Targeted delivery of anti-inflammatory therapy to rheumatoid tissue by fusion proteins containing an IL-4-linked synovial targeting peptide

We provide first-time evidence that the synovial endothelium-targeting peptide (SyETP) CKSTHDRLC successfully delivers conjugated IL-4 to human rheumatoid synovium transplanted into SCID mice. SyETP, previously isolated by in vivo phage display and shown to preferentially localize to synovial xenografts, was linked by recombinant technology to hIL-4 via an MMP-cleavable sequence. Both IL-4 and the MMP-cleavable sequence were shown to be functional. IL-4-SyETP augmented production of IL-1ra by synoviocytes stimulated with IL-1[beta] in a dose-dependent manner. In vivo imaging confirmed increased retention of SyETP-linked-IL-4 in synovial grafts which was enhanced by increasing number of copies (one to three) in the constructs. Strikingly, SyETP delivered bioactive IL-4 in vivo as demonstrated by increased pSTAT6 in synovial grafts. Thus, this study provides proof of concept for peptide-tissue-specific targeted immunotherapy in rheumatoid arthritis. This technology is potentially applicable to other biological therapies providing enhanced potency to inflammatory sites and reducing systemic toxicity

Cytotoxic, anti-inflammatory and adipogenic effects of selected flavonoids on cell lines

Naturally-occurring flavonoids have tremendous potential for producing of new therapeutic agents that provide many benefits to mankind.This study focused on the evaluation of the in vitro cytotoxic, anti-inflammatory and adipocyte differentiation effects of the selected flavonoids which were inophyllum D, calanone, and isocordataoblongic acid from Calophyllumsymingtonianum as well as morelloflavone from Garciniaprainiana on MCF 7 human breast cancer cells, RAW 264.7 macrophages and 3T3-L1 pre-adipocytes respectively. The cytotoxicity study on MCF 7 human breast cancer cells was conducted by 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide (MTT) assay. Meanwhile, the study of anti-inflammatory effects in RAW 264.7 macrophages and adipogenic effects on 3T3-L1 pre-adipocytes were conducted through nitrite determination assay and induction of adipocyte differentiation respectively. In the cytotoxicity study, inophyllum D was the only compounds that exhibited significant cytotoxic effect against MCF 7 human breast cancer with IC50 of 84 μg/mL. Further, all the compounds have shown anti-inflammatory effects in lipopolysaccharide (LPS)-induced RAW 264.7 macrophages with inhibition of nitrite concentration as compared to the positive control. Besides, all the compounds in the range of the tested concentrations also produced adipogenic effects on 3T3-L1 pre-adipocytes and this may suggest that they exhibited potential anti-hyperglycemic property which mimicking the insulin action. Thus, this study may provide significant implication in the discovery of the potential of these selected flavonoids as alternative anti-cancer, anti-inflammatory and anti-hyperglycemic drugs